BGC > Buscar Producto > Dolutegravir sodium | 1051375-19-9

Molecular Formula: C20H18F2N3NaO5
Molecular Weight: 441.3605964

Description:
Dolutegravir sodium salt is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.

• Molecular Weight:441.36
• Purity:>98%

Molecular Formula:
C20H18F2N3NaO5
Canonical SMILES:
CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+]
InChI:
InChI=1S/C20H19F2N3O5.Na/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22;/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28);/q;+1/p-1/t10-,15+;/m1./s1
InChIKey:
UGWJRRXTMKRYNK-VSLILLSYSA-M
Solubility:
In Vitro: DMSO : ≥ 4.5 mg/mL(10.20 mM) H2O : < 0.1 mg/mL(insoluble)
Appearance:
Solid powder
Application:
HIV Integrase Inhibitors
Storage: Powder: 3 years -20°C In solvent: 2 years -80°C
Synonyms:
DTG; GSK1349572; GSK 1349572; GSK-1349572