BGC > Buscar Producto > 10-Hydroxycamptothecine | 19685-09-7

Molecular Formula: C20H16N2O5

Molecular Formula: C20H16N2O5
Molecular Weight: 364.35
Hazard Symbols: Xi,T
UN Number: UN 2811 6.1 / PGIII
WGKGermany: 3

Molecular Formula: C20H16N2O5
Molecular Weight: 364.35
HS Code: 29349990

Molecular Formula: C20H16N2O5
Molecular Weight: 364,35

Assay:99% min

Description:
(±)-10-Hydroxycamptothecin is an alkaloid derived from the seed or root bark of the deciduous plant Camptotheca acuminata. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. It exhibits anticancer and antiangiogenic activities. It can be used in cosmetics material.

• Molecular Weight:364.35
• Boiling Point:820.7±65.0°C at 760 mmHg
• Melting Point:230-237°C
• Purity:≥95%

Molecular Formula:
C20H16N2O5
Canonical SMILES:
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
InChI:
InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
InChIKey:
HAWSQZCWOQZXHI-UHFFFAOYSA-N
Solubility:
Soluble in DMSO (Slightly), Methanol (Slightly, Heated)
Appearance:
Pale Yellow Powder
Storage: Store at -20°C under inert atmosphere
Synonyms:
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (±)-; (+/-)-10-Hydroxycamptothecin; 4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Description:
10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM. 10-Hydroxycamptothecin is also an impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer.

• Molecular Weight:364.35
• Boiling Point:820.7±65.0°C at 760 mmHg
• Melting Point:268-270°C
• Purity:>98%

Molecular Formula:
C20H16N2O5
Canonical SMILES:
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
InChI:
InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
InChIKey:
HAWSQZCWOQZXHI-FQEVSTJZSA-N
Solubility:
Soluble in Chloroform, DMSO (Slightly), Ethyl acetate, Methanol (Slightly, Heated)
Appearance:
Light Yellow to Yellow Solid
Application:
anti-cancer
Storage: Store at -20°C
Synonyms:
10-Hydroxycamptothecin; Irinotecan Related Compound A; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-; Camptothecine, 10-hydroxy-; (+)-10-Hydroxycamptothecin; (S)-10-Hydroxycamptothecin; 10-HCPT; 10-Hydroxycamptothecin; 10-Hydroxycamptothecine; Hydroxycamptothecin; NSC 107124; USP Irinotecan Related Compound A; Irinotecan USP Related Compound A

Purity: 98+%
Smile code: O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O
MDL Number: MFCD02093100
MolFormula: C20H16N2O5
MolWeight: 364.3515
Available in stock: 166.569

Smile code:
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O
MDL Number:
MFCD02093100
Purity :
98+%
Available in stock:
161.817 g