BGC > Buscar Producto > NLG919 | 1402836-58-1

Molecular Formula: C18H22N2O
Molecular Weight: 282.39

Description:
NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs).

• Molecular Weight:282.38
• Melting Point:143 - 146°C
• Purity:> 98%

Molecular Formula:
C18H22N2O
Canonical SMILES:
C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
InChI:
1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
InChIKey:
YTRRAUACYORZLX-UHFFFAOYSA-N
Solubility:
DMSO 15 mg/mL heating; Water < 1 mg/ml
Appearance:
White solid
Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Synonyms:
GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078.