Description:
Cilofexor is a farnesoid X receptor (FXR) agonist. Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay).
- Molecular Weight:586.9
- Purity:≥98%
Molecular Formula:
C28H22Cl3N3O5
Canonical SMILES:
OC(C1=CC=NC(N2CC(C3=C(Cl)C=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3)(O)C2)=C1)=O
InChI:
InChI=1S/C28H22Cl3N3O5/c29-20-2-1-3-21(30)24(20)25-18(26(39-33-25)15-4-5-15)12-38-17-6-7-19(22(31)11-17)28(37)13-34(14-28)23-10-16(27(35)36)8-9-32-23/h1-3,6-11,15,37H,4-5,12-14H2,(H,35,36)
InChIKey:
KZSKGLFYQAYZCO-UHFFFAOYSA-N
Solubility:
Soluble in DMSO.
Appearance:
Crystalline Solid
Synonyms:
2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]-4-pyridinecarboxylic acid Más detalles se encuentran
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