Description:
Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA.
- Molecular Weight:438.3
- Boiling Point:603.6ºC at 760 mmHg
- Melting Point:169.5-170ºC
- Purity:>98%
Molecular Formula:
C21H20ClNO5.HCl
Canonical SMILES:
CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
InChI:
InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1
InChIKey:
LGMSNQNWOCSPIK-LWHGMNCYSA-N
Solubility:
In Vitro: H2O : ≥ 20 mg/mL(45.63 mM) DMF : 7.69 mg/mL(17.55 mM;Need ultrasonic)
Appearance:
Light yellow to khaki (Solid)
Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms:
NSC 649890 HCl; NSC649890 HCl; NSC-649890 HCl Más detalles se encuentran
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