Description:
ARS-1620 is a potent and selective KRAS-G12C inhibitor. ARS-1620 achieves rapid and sustained in vivo target occupancy to induce tumor regression.
Molecular Formula:
C21H17ClF2N4O2
Canonical SMILES:
C=CC(=O)N1CCN(CC1)C2=C3C=C(C(=C4C(=O)C=CC=C4F)C(=C3NC=N2)F)Cl.S
InChI:
InChI=1S/C21H17ClF2N4O2.H2S/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25-11-26-21)18-14(23)4-3-5-15(18)29;/h2-5,10-11H,1,6-9H2,(H,25,26);1H2
InChIKey:
KBKGRXPEDCMRAY-UHFFFAOYSA-N
Synonyms:
ARS-1620; ARS 1620; ARS1620; BCP29125; BCP 29125; BCP-29125; 6-[6-chloro-8-fluoro-4-(4-prop-2-enoylpiperazin-1-yl)-1H-quinazolin-7-ylidene]-5-fluorocyclohexa-2,4-dien-1-one sulfane Weitere Informationen finden Sie
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