BGC > Produktsuche > Intedanib | 656247-17-5

Molecular Formula: C31H33N5O4
Molecular Weight: 539.62482

Molecular Formula: C31H33N5O4
Molecular Weight: 539.62482

Molecular Formula: C20H16ClNO5
Molecular Weight: 385.79774

Description:
Nintedanib-[13C,d3] is the labelled analogue of Nintedanib. Nintedanib is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β. It is used for the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).

• Molecular Weight:543.65
• Purity:≥95%

Molecular Formula:
C30[13C]H30D3N5O4
Canonical SMILES:
CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
InChI:
InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,33,38H,15-18,20H2,1-3H3/i1+1D3
InChIKey:
CPMDPSXJELVGJG-KQORAOOSSA-N
Solubility:
Soluble in DMSO
Appearance:
Pale Yellow to Yellow Solid
Storage: Store at-20°C
Synonyms:
Nintedanib 13CD3; [13C,2H3]-BIBF 1120; [13C,2H3]-Intedanib; [13C,2H3]-Vargatef; methyl (Z)-3-(((4-(N-methyl-2-(4-(methyl-13C-d3)piperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate; Ofev-13C,d3

Description:
Nintedanib is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. It is used for the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).

• Molecular Weight:539.62
• Melting Point:>237°C (dec.)
• Purity:≥98%

Molecular Formula:
C31H33N5O4
Canonical SMILES:
CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
InChI:
InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,33,38H,15-18,20H2,1-3H3
InChIKey:
CPMDPSXJELVGJG-UHFFFAOYSA-N
Solubility:
Soluble to 9.66 mg/L in water.
Appearance:
Light Green to Light Yellow Solid
Synonyms:
Vargatef; BIBF-1120; BIBF 1120; BIBF1120; Intedanib