BGC > Produktsuche > (S)-2-(4,6-Dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid | 177036-94-1

Molecular Formula: C22H22N2O4
Molecular Weight: 378.42
HS Code: 29335990

Description:
Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH).

• Molecular Weight:378.42
• Melting Point:>150 °C
• Purity:>98%

Molecular Formula:
C22H22N2O4
Canonical SMILES:
CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InChI:
InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
InChIKey:
OUJTZYPIHDYQMC-LJQANCHMSA-N
Solubility:
Ambrisentan is practically insoluble in aqueous solutions at low pH. Solubility increases at higher pH.
Appearance:
White to off white solid
Application:
Antihypertensive Agents
Synonyms:
BSF-208075; BSF208075; BSF 208075; LU-208075; LU208075; LU 208075; Letairis; Volibris

Purity: 98%
Smile code: O=C(O)[C@@H](OC1=NC(C)=CC(C)=N1)C(C2=CC=CC=C2)(OC)C3=CC=CC=C3
MDL Number: MFCD08672619
MolFormula: C22H22N2O4
MolWeight: 378.4211
Available in stock: 47.412

Smile code:
O=C(O)[C@@H](OC1=NC(C)=CC(C)=N1)C(C2=CC=CC=C2)(OC)C3=CC=CC=C3
MDL Number:
MFCD08672619
Purity :
98%
Available in stock:
32.721 g