BGC > Produktsuche > 2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid | 594839-88-0

Molecular Formula: C14H7Cl2NO3
Molecular Weight: 308.12

Description:
Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. It is a drug for the amelioration of transthyretin-related hereditary amyloidosis. It functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein and binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR.

• Molecular Weight:308.12
• Purity:>98%

Molecular Formula:
C14H7Cl2NO3
Canonical SMILES:
C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
InChI:
InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
InChIKey:
TXEIIPDJKFWEEC-UHFFFAOYSA-N
Synonyms:
Fx-1006A; Vyndaqel