BGC > Produktsuche > Selumetinib | 606143-52-6

Molecular Formula: C17H15BrClFN4O3
Molecular Weight: 457.685
HS Code: 29349990

Appearance	Beige powder.
Purity	99% min

Description:
Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells. MEK 1 and 2 are dual-specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various tumor cell types, and are drivers of diverse cellular activities, including cellular proliferation. Check for active clinical trials or closed clinical trials using this agent.

• Molecular Weight:457.684
• Purity:>98%

Molecular Formula:
C17H15BrClFN4O3
Canonical SMILES:
CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
InChI:
InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey:
CYOHGALHFOKKQC-UHFFFAOYSA-N
Appearance:
white solid powder
Storage: Powder stores in -20ºC directly, which is effective for a period of 2 years.
Synonyms:
ARRY-142886; ARRY 142886; ARRY142886; AZD6244; AZD-6244; AZD 6244; ARRY-886; ARRY886; ARRY 886