BGC > Produktsuche > Sorafenib tosylate

Appearance	Pale Yellow or almost white crystalline powder
Melting point	225.0-235.0℃
Solubility	Soluble in DMSO at 200mg/ml; very poorly soluble in ethanol; very poorly in water.
Identification
(1) MS
(2) UV
(3) 1H-NMR
Loss on drying	≤ 0.5%
Heavy metals	≤ 10ppm
Ordinary impurities
Total impurities	≤ 1.0%
Assay(HPLC)	99.0%~101.0%

Molecular Formula: C21H16ClF3N4O3
Molecular Weight: 464.83
HS Code: 29350090

Assay:99.0%min

Description:
Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.

• Molecular Weight:637.03
• Boiling Point:523.3 °C at 760 mmHg
• Melting Point:229-232 °C
• Purity:≥ 95%

Molecular Formula:
C28H24ClF3N4O6S
Canonical SMILES:
CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
InChI:
InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)
InChIKey:
IVDHYUQIDRJSTI-UHFFFAOYSA-N
Solubility:
Soluble in Methanol, DMSO, DMF
Appearance:
White to Off-white Solid
Storage: 2-8 °C
Synonyms:
Sorafenib p-toluenesulfonate; BAY 43-9006 Mono-p-tosylate; BAY 54-9085; Nexavar(R); 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate); 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-, mono(4-methylbenzenesulfonate); Bay 43-9006

Purity: 98%
Smile code: O=C(C1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=C1)NC.O=S(C4=CC=C(C)C=C4)(O)=O
MDL Number: MFCD08235032
MolFormula: C28H24ClF3N4O6S
MolWeight: 637.0266
Available in stock: 426.768