BGC > Produktsuche > Ykl-06-061 | 2172617-15-9

Molecular Formula: C30H37N7O2
Molecular Weight: 527.66048

Description:
YKL-06-061 is a small molecule serine/threonine-protein kinase SIK1 inhibitor (Ki = 6.56 nM) that is hopefully developed to be a dermatologic drug impacting UV protection and skin cancer risk. It causes a dose-dependent increase in microphthalmia-associated transcription factor (MITF) mRNA expression during 3-hour function in normal human melanocytes, UACC62 human melanoma cells, and UACC257 human melanoma cells.

• Molecular Weight:527.67
• Boiling Point:719.8±70.0 °C at 760 mmHg

Molecular Formula:
C30H37N7O2
Canonical SMILES:
CC1=C(C(=CC=C1)C)N2CC3=CN=C(N=C3N(C2=O)C4CCC4)NC5=C(C=C(C=C5)N6CCN(CC6)C)OC
InChI:
InChI=1S/C30H37N7O2/c1-20-7-5-8-21(2)27(20)36-19-22-18-31-29(33-28(22)37(30(36)38)23-9-6-10-23)32-25-12-11-24(17-26(25)39-4)35-15-13-34(3)14-16-35/h5,7-8,11-12,17-18,23H,6,9-10,13-16,19H2,1-4H3,(H,31,32,33)
InChIKey:
GVBAXIVNAHMIGH-UHFFFAOYSA-N
Application:
a potential dermatologic drug
Synonyms:
YKL06-061; YKL 06-061; YKL-06061