BGC > Produktsuche > 2-[3,5-bis-(Trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide | 290297-26-6
Lieferanten für CAS
290297-26-6
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Daten | CAS |
290297-26-6 | Formula |
C30H32F6N4O |
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10 Registerierte Lieferanten
Dayang Chem (Hangzhou) Co.,Ltd.
P.R.China
Xingrui Industry Co., Limited
P.R.China
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C30H32F6N4O Molecular Weight: 578.61
Molecular Formula: C30H32F6N4O Molecular Weight: 578.59 Weitere Informationen finden Sie hier
Chemvon Biotechnology Co. Ltd.
P.R.China
Hangzhou Lingrui Chemical Co., Ltd.
P.R.China
Skyrun Industrial Co., Ltd.
P.R.China
BOC Sciences
USA
Description: Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. On 10/10 2014 FDA approved netupitant for the treatment of nausea and vomiting in patients undergoing cancer chemotherapy. - Molecular Weight:578.603
- Melting Point:158-161 °C
- Purity:>98%
Molecular Formula: C30H32F6N4O Canonical SMILES: CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C InChI: InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3 InChIKey: WAXQNWCZJDTGBU-UHFFFAOYSA-N Appearance: Solid powder Synonyms: AGE94200; AGE-94200; AGE 94200;Ro 67-3189; Ro-67-3189; Ro67-3189; CHEBI441603; CID6451149; D05152; UNII-7732P08TIR, CHEMBL206253, AG-E-94200, Netupitant Weitere Informationen finden Sie hier
Ambeed, Inc.
USA
Purity: 98% Smile code: O=C(N(C)C1=C(C2=CC=CC=C2C)C=C(N3CCN(C)CC3)N=C1)C(C)(C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4 MDL Number: MFCD25976831 MolFormula: C30H32F6N4O MolWeight: 578.5917 Available in stock: 89.509 Weitere Informationen finden Sie hier
BLD Pharmatech Ltd
P.R.China
Smile code:O=C(N(C)C1=C(C2=CC=CC=C2C)C=C(N3CCN(C)CC3)N=C1)C(C)(C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4 MDL Number:MFCD25976831 Purity :98% Available in stock: 87.983 g Weitere Informationen finden Sie hier
Chemlyte Solutions
P.R.China
Weitere Informationen finden Sie hier
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