BGC > Produktsuche > Andrographolide | 5508-58-7

Assay (Andrographolide) (HPLC)	≥ 98%
Chemical Control
Pesticides	Negative
Heavy metals	<10ppm
Physical control
Appearance	White Powder
Odor	Characteristic
Particle size	100% pass 80 mesh
Moisture	<3%
Microbiological
Total of bacteria	<1000/g
Fungi	<100/g
Salmonella	Negative
Coli	Negative

Molecular Formula: C20H30O5
Molecular Weight: 350.45
Hazard Symbols: Xn
WGKGermany: 3
HS Code: 29322980

Description:
Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. It has the effects of dispelling heat, detoxification, anti-inflammatory and relieving pain.

• Molecular Weight:350.45
• Boiling Point:557.3±50.0 °C at 760 mmHg
• Melting Point:229-232ºC
• Purity:>98%

Molecular Formula:
C20H30O5
Canonical SMILES:
CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O
InChI:
InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1
InChIKey:
BOJKULTULYSRAS-OTESTREVSA-N
Solubility:
In Vitro: DMSO : 100 mg/mL(285.35 mM;Need ultrasonic) H2O : < 0.1 mg/mL(insoluble) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution
Appearance:
Powder
Application:
anticancer
Storage: Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Synonyms:
(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methyle ne-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxy-2-oxolanone

Purity: 98+%
Smile code: O=C1OC[C@@H](O)/C1=CC[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@H](O)CC[C@@]23C)=C
MDL Number: MFCD07778082
MolFormula: C20H30O5
MolWeight: 350.4492
Available in stock: 3852.957

Smile code:
O=C1OC[C@@H](O)/C1=CC[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@H](O)CC[C@@]23C)=C
MDL Number:
MFCD07778082
Purity :
98+%
Available in stock:
2811.705 g

Andrographolide is a Labdan diterpene compound produced by andrographis paniculata plant. It has a wide range of therapeutic applications, including anti-inflammatory and anti-platelet aggregation activities as well as potential anti-tumor properties. Since andrographolide has multiple therapeutic activities, the drug has several mechanisms of action. The anti-inflammatory effect of the drug seems to be related to the inhibition of nitric oxide (NO) production by macrophages. The drug can activate the NO/cyclic GMP pathway and inhibit the phospholipase C γ2 (PLC γ2)/protein kinase C (PKC) and PI3K/AKT-MAPK signaling pathways in activated platelets to inhibit platelet aggregation. In activated platelets, these three signaling pathways are downstream of integrin activation mediated by collagen binding, and affect the association of fibrinogen with its receptor. In addition, andrographolide can exert its anti-cancer activity by inducing cell cycle arrest in G0/G1 phase and stimulating the proliferation and activation of lymphocytes. These processes may lead to a decrease in the proliferation of tumor cells and an increase in immune cell toxicity.

NCI Thesaurus (NCIt)
Andrographolide is a Labdan diterpenoid isolated from the leaves and roots of Andrographis paniculata. It has anti-HIV, anti-inflammatory and anti-tumor properties. It has the effects of metabolites, anti-inflammatory drugs, anti-HIV agents and anti-tumor agents. It is a γ-lactone, a primary alcohol, a secondary alcohol, a Labdan diterpene compound and a carbon bicyclic compound.

Cheby
Andrographolide (HMPL-004) is a plant product extracted from naturally occurring herbs in China. The herb has a wide history of use in Chinese medicine for the treatment of upper respiratory tract infections and other inflammations and infectious diseases.