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Molecular Formula: C3H7O *
Molecular Weight: 59.08708
WGKGermany: 1
HS Code: 39129000

Low-substituted hydroxypropyl cellulose is a non-ionic, water insoluble functional disintegrant. It can improve stability for oxygen and water sensitive APIs and has an anti-capping effect due to the fibrous nature of the particle.

L-HPC is a low-substituted hydroxypropyl ether of cellulose within a small portion of the hydroxypropyl groups in the glucose unit. Whereas hydroxypropylcellulose (MS*=3) is soluble in both water and alcohol, L-HPC (MS*=0.2-0.4) swells in water and is insoluble.

L-HPC is used as a binder and a disintegrant for solid dosage forms. It was brought onto the market in 1977, and then listed in the JP in 1986, in the NF in 1990 and in the EP in 2016. This product exhibits a wide range of compatibility with many active substances. It is a suitable binder and disintegrant for a formulation study.

Hydroxypropyl cellulose (HPC), or hydroxypropylcellulose, also referred to its abbreviation HPC. It is made from cellulose and used as a thickening agent in food or pharma.

As HPC has a large number of hydroxypropoxy groups than L-HPC, this making HPC soluble in water while L-HPC is not. Due to this characteristic, HPC can be used in aqueous solution whereas L-HPC cannot.

HPC
It is cellulose obtained directly from strains of fibrous plant material and partially etherified with hydroxypropyl groups. HPC can be used as an emulsifier, film former, protective colloid, stabilizer, suspending agent, or thickener in food, may be also used as a binder in dietary supplements.


The following is hydroxypropoxyl groups specification of HPC:
Assay: Not more than 80.5 %
Numbers:Not more than 4.6 per anhydroglucose unit
Average Numbers:3.5 hydroxypropoxy groups per anhydroglucose unit
Molecular Weight:From about 30,000 to 1,000,000

Alternative name	Hydroxypropylcellulose (nominale Viskosität 300 mPa s)
Further description	KLUCEL GF®, Hydroxypropylcellulosum
Monograph	Ph.Eur.9.0
Pharmaceutical status	free
INCI	Hydroxypropylcellulose
UEXDES	Chemicals solid

Appearance: white powder
Purity: 99%
Packaging: 25kg/drum, or according to customers request.