BGC > Produktsuche > Ipatasertib | 1001264-89-6

Molecular Formula: C24H32ClN5O2
Molecular Weight: 457.99618

Description:
Ipatasertib, also known as GDC-0068 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

• Molecular Weight:458.0

Molecular Formula:
C24H32ClN5O2
Canonical SMILES:
CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O
InChI:
InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
InChIKey:
GRZXWCHAXNAUHY-NSISKUIASA-N
Appearance:
Solid powder
Application:
Antineoplastic Agents
Synonyms:
GDC-0068; GDC0068; GDC 0068; RG7440; RG-7440; RG 7440; Ipatasertib