Product Name: Glycyrrhizic acid ammonium salt
Synonyms:.alpha.-D-Glucopyranosiduronicacid,(3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl2-O-.beta.-D-glucopyranuronosyl-,monoammoniumsalt; ammoniate; Ammoniumglycynhizinato; ammoniumglycyrrhizate; glycyrram
CAS:53956-04-0
MF:C42H65NO16
MW:839.96
EINECS:258-887-7
Melting point:>200 °C (dec.)
Refractive index：49 °C (C=1.5, EtOH)
Stability: Stable.
Package: 25kg/drum
Purity: 98%
Chemical properties:
White needle crystal or crystalline powder, with a strong sweetness, sweetness of sucrose 50 to 100 times. Melting at 208-212 ° C. Dissolved in ammonia, not soluble in acetic acid. Mice oral LD50 greater than 10g / kg.
Usage:
Flavoring agent; Flavoring agent; Surface active agent. The pharmaceutical industry for cough and phlegm, treatment of liver disease.
Brief manufacture process:
To Glycyrrhizic acid crude (content about 50%, weight method) as raw materials, acidic ethanol as extraction agent, refined derived. The crude glycyrrhizic acid (50 g) was added to 170 mL of 95% ethanol (pH 3.5 to 4.0) acidified with hydrochloric acid and stirred at 40-50 ° C for 4 h. Filtration with 100mL ethanol residue in the same extraction conditions 3h. The combined extract, stirring dropwise ammonia or ammonia, so that the solution of Ph value of 7.2 to 7.5, 0.5h at room temperature so that the complete precipitation. Precipitation for the glycyrrhizic acid triammonium salt, with the right amount of acetic acid to make it into a paste-like dispersion, if necessary, slightly heating, standing 1h after the filter, to convert it into an ammonium salt. Crystallization with a small amount of glacial acetic acid after washing 1 to 2 times, in yellow crude. With 75% ethanol decolorization of activated carbon recrystallization, the white crystal 15.5g, yield 61%, purity ≥ 98%.
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