Description:
5-(Hydroxymethyl)-2'-deoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM). 5-(Hydroxymethyl)-2'-deoxyuridine acts synergistically with 5-fluorouracil (5-FU) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.
- Molecular Weight:258.23
- Melting Point:>168°C (dec.)
- Purity:≥95%
Molecular Formula:
C10H14N2O6
Canonical SMILES:
C1C(C(OC1N2C=C(C(=O)NC2=O)CO)CO)O
InChI:
InChI=1S/C10H14N2O6/c13-3-5-2-12(10(17)11-9(5)16)8-1-6(15)7(4-14)18-8/h2,6-8,13-15H,1,3-4H2,(H,11,16,17)/t6-,7+,8+/m0/s1
InChIKey:
IPAVKOYJGUMINP-XLPZGREQSA-N
Solubility:
Soluble in DMSO (Slightly, Sonicated), Methanol (Slightly, Heated), Water (Slightly)
Appearance:
White to Off-white Solid
Application:
Antineoplastic Agents
Storage: Store at -20°C under inert atmosphere
Synonyms:
a-hydroxythymidine; 5-Hydroxymethyl-2'-deoxyuridine; alpha-Hydroxythymidine; 5-Hydroxymethyldeoxyuridine; HMdU; 5-HMdU; 2'-Deoxy-5-(hydroxymethyl)uridine; 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-(2-hydroxymethyl)pyrimidine-2,4(1H,3H)-dione Weitere Informationen finden Sie
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