Lieferanten für CAS
698387-09-6
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Daten | CAS |
698387-09-6 | Formula |
C30H29ClN6O3 |
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13 Registerierte Lieferanten
Amadis Chemical Company Limited
P.R.China
Weitere Informationen finden Sie hier
Hangzhou Meite Industry Co., Ltd (Hangzhou Meite Chemical Co., Ltd)
P.R.China
Capot Chemical Co., Ltd.
P.R.China
Weitere Informationen finden Sie hier
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C30H29ClN6O3 Molecular Weight: 557.04266 HS Code: 29334900
Guangzhou Topwork Chemical Co., Ltd.
P.R.China
Aea.ltd
P.R.China
Hangzhou Zhongqi Chem Co., Ltd
P.R.China
Finetech Industry Limited
P.R.China
Weitere Informationen finden Sie hier
Skyrun Industrial Co., Ltd.
P.R.China
BOC Sciences
USA
Description: Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. - Molecular Weight:557.051
- Melting Point:185-187 °C
- Purity:>98%
Molecular Formula: C30H29ClN6O3 Canonical SMILES: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C InChI: InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ InChIKey: JWNPDZNEKVCWMY-VQHVLOKHSA-N Appearance: Solid powder Synonyms: HKI-272; HKI 272; HKI272; PB-272; PB 272; PB 272. Weitere Informationen finden Sie hier
Chemos GmbH & Co. KG
Germany
BuGuCh & Partners
Germany
Santa Cruz Biotechnology, Inc.
USA
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