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Molecular Formula: C14H14Cl2N4OS
Molecular Weight: 357.26

Description:
Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity. A phase II study of nolatrexed in 2007 in advanced HCC patients demonstrated minimal activity and significant stomatitis.

• Molecular Weight:357.25
• Melting Point:>240°C (dec.)
• Purity:98%

Molecular Formula:
C14H14Cl2N4OS
Canonical SMILES:
O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl.[H]Cl
InChI:
InChI=1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H
InChIKey:
PJKVJJYMWOCLIJ-UHFFFAOYSA-N
Solubility:
Soluble in Methanol, Water
Appearance:
Off-white to Pale Yellow Solid
Storage: Store at -20°C, sealed storage, away from moisture
Synonyms:
AG 337; Thymitaq; 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride; 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)-1,4-dihydroquinazolin-4-one dihydrochloride; 3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)quinazoline dihydrochloride