Description:
PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice.
- Molecular Weight:482.49
- Purity:≥97% by HPLC
Molecular Formula:
C25H35N3O2·2HCl
Canonical SMILES:
CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)C3CCNC3.Cl.Cl
InChI:
InChI=1S/C25H35N3O2.2ClH/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3;;/h6-13,23,26H,4-5,14-19H2,1-3H3;2*1H/t23-;;/m1../s1
InChIKey:
GSUZWFZKTIOWTI-MQWQBNKOSA-N
Solubility:
In vitro: 10 mM in DMSO
Appearance:
White to light brown (Solid)
Storage: 4°C, sealed storage, away from moisture
Synonyms:
PF-429242 dihydrochloride; PF429242 dihydrochloride Weitere Informationen finden Sie
hier