BGC > Buscar Producto > (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | 2097381-85-4

Molecular Formula: C27H33N5O4S
Molecular Weight: 523.64702

Description:
VH-298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd value of 80-90 nM) that could block VHL and HIF-α interactions. VH-298 can be used in PROTAC technology.

• Molecular Weight:523.65
• Purity:≥98% by HPLC

Molecular Formula:
C₂₇H₃₃N₅O₄S
Canonical SMILES:
O=C(N[C@@H](C(C)(C)C)C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)O)=O)C4(C#N)CC4
InChI:
1S/C27H33N5O4S/c1-16-21(37-15-30-16)18-7-5-17(6-8-18)12-29-23(34)20-11-19(33)13-32(20)24(35)22(26(2,3)4)31-25(36)27(14-28)9-10-27/h5-8,15,19-20,22,33H,9-13H2,1-4H3,(H,29,34)(H,31,36)/t19-,20+,22-/m1/s1
InChIKey:
NDVQUNZCNAMROD-RZUBCFFCSA-N
Solubility:
In DMSO: ≥ 83.3 mg/mL (159.08 mM) * ´≥´ means soluble, but saturation unknown.
Application:
Enzyme Inhibitors
Storage: Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month
Synonyms:
(2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; EX-A1505; VH 298; VH298; VH-298

Formula:
C27H33N5O4S
Mol Weight:
523,65g/mol