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Molecular Formula: C10H9N3O
Molecular Weight: 187.2
Hazard Symbols: T,Xn
UN Number: UN 2811 6.1/PG 3
WGKGermany: 3
PackingGroup: III
HS Code: 29333999

Description:
Amrinone is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is a simple, non-glycoside cardiotonic agent. It provides protection against ischemia-reperfusion injury in kidney, liver, and heart. It has the ability to stimulate calcium ion influx into the cardiac cell. It is used in the treatment of congestive heart failure. It increases cardiac contractility as a vasodilator. It acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. It is a drug that may improve the prognosis in patients with congestive heart failure. It has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). It was developed by Sanofi and has been listed.

• Molecular Weight:187.20
• Boiling Point:451.5±45.0 °C | Condition: Press: 760 Torr
• Melting Point:295 °C (decomp)
• Purity:98%

Molecular Formula:
C10H9N3O
Canonical SMILES:
C1=CN=CC=C1C2=CNC(=O)C(=C2)N
InChI:
InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
InChIKey:
RNLQIBCLLYYYFJ-UHFFFAOYSA-N
Solubility:
DMSO (Slightly), Methanol (Slightly)
Appearance:
Pale Beige to Yellow Solid
Application:
Amrinone is a simple, non-glycoside cardiotonic agent. It provides protection against ischemia-reperfusion injury in kidney, liver, and heart. It is used in the treatment of congestive heart failure. It increases cardiac contractility as a vasodilator.
Storage: 2-8°C
Synonyms:
Inamrinone;Wincoram;Inocor;Cordemcura;Win-40680;Win40680;3-Amino-5-pyridin-4-yl-1H-pyridin-2-one