BGC > Produktsuche > 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol | 805239-56-9

Molecular Formula: C20H11F6N3O
UN Number: UN 2811 6.1 / PGIII

Description:
PHTPP, a pyrazolo[1,5-α]pyrimidine-based ligand, is a selective estrogen ERβ receptor antagonist that displays 36-fold selectivity over ERα. This compound has been used to selectively target ERβ in the study of the opposing effects of hormone therapy on tumors expressing either ER subtype.

• Molecular Weight:423.31
• Purity:≥99% by HPLC

Molecular Formula:
C20H11F6N3O
Canonical SMILES:
C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F
InChI:
InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H
InChIKey:
AEZPAUSGTAHLOQ-UHFFFAOYSA-N
Solubility:
DMSO to 33 mM; ethanol to 100 mM
Appearance:
Yellow solid
Storage: Store in a cool and dry place (or refer to the Certificate of Analysis).
Synonyms:
4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol