BGC > Produktsuche > Zidovudine

Molecular Formula: C10H13N5O4
Molecular Weight: 267,24

Description:
Zidovudine is a nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC50 = 3 nM) with low cytotoxicity (CC50 > 5 μM). It is commonly used in combination therapy to slow the replication of HIV in vivo.

• Molecular Weight:267.24
• Melting Point:113-115°C
• Purity:≥95%

Molecular Formula:
C10H13N5O4
Canonical SMILES:
CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
InChI:
InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChIKey:
HBOMLICNUCNMMY-XLPZGREQSA-N
Solubility:
Soluble in DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
Appearance:
White Crystalline Powder
Application:
Anti-hiv agents; antimetabolites; antimetabolites, Antineoplastic; reverse transcriptase inhibitors
Storage: Store at 2-8°C
Synonyms:
3'-Azido-3-deoxythymidine; AZT; BWA509U; BWA 509U; BWA-509U; ZDV; Azidothymidine; Retrovir; Timazid; NSC 602670; 3'-Azido-2',3'-dideoxythymidine; 1-(3-Azido-2,3-dideoxy-β-D-glycero-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; 1-[(2R,4S,5S)-4-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidin-2,4(1H,3H)-dione; 1-(3-Azido-2,3-dideoxy-β-D-ribofuranosyl)thymine