BGC > Produktsuche > Tetracycline hydrochloride | 64-75-5

Characteristics	A white or yellowish white powder .Odorless or almost.bygroscopic
Identification A B C	The positive reaction.
Solubility	Very soluble in water, insoluble in acetone , chloroform, ether.
Specific optical rotation	+53.5°~ +59.0°
Acidity of alkalinity	5.0~7.5
Impurity A	2%max
Impurity C	3% ~15%
Any other impurity	not more than the area of the principal peak in the chromatogram obtained with RS(B)5%
Total other impurity	not more than 3times the area of the principal peak in the chromatogram obtained with RS(B)15%
Disregard limit	ae of the principal peak in the chromatogram obtained with RS(C)1%
Loss on drying (pct)	max8.0
Sulphate	27.0-31.0%
Sulphated ash	1% max
Microcount limit test	NMT 500 col/g
Microcount-yeast and molds	NMT 10 col/g
Microcount-Escherichia coli	Absent
Microcount-Staphy lococcus aureus	Absent
Microcount-Pseudo monas	Absent
Assay	≥ 680I.U./mg (DRY)

Molecular Formula: C22H24N2O8.HCl
Molecular Weight: 480.90

USP/EP

Antibiotic

Alternative name	Tetracyclinhydrochlorid, API (mikrobielle Herkunft)
Further description	Tetracyclini hydrochloridum
Monograph	Ph.Eur.9.0
Pharmaceutical status	prescription only
UEXDES	Chemicals solid

Description:
Tetracycline hydrochloride is the hydrochloride form of tetracycline, a broad-spectrum polyketide antibiotic. It inhibits protein synthesis in bacteria by blocking the binding of aminoacyl-tRNA to bacterial ribosomes. It can be used to treat infectious diseases caused by certain Gram-positive and -negative bacteria, Rickettsia, Mycoplasma, etc.

• Molecular Weight:480.90
• Boiling Point:799.4°C at 760 mmHg
• Melting Point:>198°C (dec.)
• Purity:>98%

Molecular Formula:
C22H24N2O8.HCl
Canonical SMILES:
CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
InChI:
InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25-26,29,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
InChIKey:
YCIHPQHVWDULOY-FMZCEJRJSA-N
Solubility:
Soluble in Ethanol, Methanol, DMF, DMSO, Water
Appearance:
Light Yellow to Yellow Solid
Application:
Anti-Bacterial Agents
Storage: Store at -20°C
Synonyms:
HLS 831; HLS831; HLS-831; [4S-(4α,4aα,5aα,6β,12aα]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-Naphthacenecarboxamide Hydrochloride; (-)-Tetracycline Hydrochloride; Achromycin; Imex; Tetracyn