BGC > Produktsuche > Cobimetinib | 934660-93-2

Molecular Formula: C21H21F3IN3O2
Molecular Weight: 531.3100196
HS Code: 29333990

Description:
Cobimetinib (GDC-0973, RG7420) is a potent, orally available and highly selective MEK1 inhibitor with IC50 of 4.2 nM. It shows more than 100-fold selectively for MEK1 over MEK2 when tested against a panel of more than 100 serine-threonine and tyrosine kinases and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.

• Molecular Weight:531.31
• Purity:≥98%

Molecular Formula:
C21H21F3IN3O2
Canonical SMILES:
C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
InChI:
InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1
InChIKey:
BSMCAPRUBJMWDF-KRWDZBQOSA-N
Appearance:
Crystalline Solid
Synonyms:
XL518; GDC-0973; RG7420