Description:
Rapamycin is an mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines.
- Molecular Weight:914.19
- Boiling Point:973.0°C at 760 mmHg
- Melting Point:183-185°C
- Purity:>98%
Molecular Formula:
C51H79NO13
Canonical SMILES:
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
InChI:
InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChIKey:
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Solubility:
Soluble in DMSO (25 mg/ml), ethanol (up to 50 mg/ml), chloroform (5 mg/ml), methanol (25 mg/ml), ether, and acetone. Limited water solubility.
Appearance:
White Crystalline Powder
Application:
antifungal and antineoplastic agent
Storage: Store at -20°C
Synonyms:
Sirolimus; (-)-Rapamycin; AY 22989; AY-22989; I-2190A; NSC 226080; RAPA; RAP; RPM; SLM; WY-090217; Everolimus EP Impurity A Weitere Informationen finden Sie
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