BGC > Produktsuche > Eltoprazine hydrochloride | 98206-09-8

Molecular Formula: C12H16N2O2.ClH
Molecular Weight: 256.731

Description:
Eltoprazine hydrochloride is the hydrochloride form of Eltoprazine which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc.. It is in clinical stage 3.

• Molecular Weight:256.73
• Melting Point:256-258 °C
• Purity:>98 %

Molecular Formula:
C12H17N2O2Cl
Canonical SMILES:
C1CN(CCN1)C2=C3C(=CC=C2)OCCO3.Cl
InChI:
InChI=1S/C12H16N2O2.ClH/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12;/h1-3,13H,4-9H2;1H
InChIKey:
JFSOSUNPIXJCIX-UHFFFAOYSA-N
Solubility:
DMSO: ≥ 31 mg/mL, H2O: ≥ 28 mg/mL
Appearance:
White to beige powder
Application:
Eltoprazine hydrochloride has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders.
Storage: -20°C Freezer
Synonyms:
Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride;1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride;DU-28853 hydrochloride;DU28853 hydrochloride