BGC > Product Search > SB525334

Description :
SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6.

• Molecular Weight :343.42494
• Purity :> 98%

Molecular Formula :
C21H21N5
Canonical SMILES :
CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
InChI :
InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChIKey :
DKPQHFZUICCZHF-UHFFFAOYSA-N
Synonyms :
SB525334; SB-525334; SB 525334

More details are to be found here

Description :
SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6.

• Molecular Weight :343.42494
• Purity :> 98%

Molecular Formula :
C21H21N5
Canonical SMILES :
CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
InChI :
InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChIKey :
DKPQHFZUICCZHF-UHFFFAOYSA-N
Synonyms :
SB525334; SB-525334; SB 525334

More details are to be found here