Description :
Tafamidis-[d3] is deuterium labelled Tafamidis. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, showing comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis.
Molecular Formula :
C14H4D3Cl2NO3
Canonical SMILES :
C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
InChI :
InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)/i1D,2D,5D
InChIKey :
TXEIIPDJKFWEEC-FYFKOAPZSA-N
Appearance :
Crystalline Solid
Storage : -20°C
Synonyms :
Tafamidis-d3; d3-Tafamidis
More details are to be found
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