BGC > Product Search > AZD 9291

Molecular Formula: C28H33N7O2
Molecular Weight: 499.61
HS Code: 29339900

Molecular Formula: C28H33N7O2
Molecular Weight: 499.61
HS Code: 29339900

Molecular Formula: C28H33N7O2
Molecular Weight: 499.61
HS Code: 29339900

Description :
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 µM, respectively).

• Molecular Weight :499.61
• Purity :98%

Molecular Formula :
C28H33N7O2
Canonical SMILES :
CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
InChI :
InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)
InChIKey :
DUYJMQONPNNFPI-UHFFFAOYSA-N
Appearance :
White to off-white powder
Application :
For research used only
Synonyms :
Mereletinib; EGFR inhibitor; AZD9291; AZD 9291

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