BGC > Product Search > LY2784544 | 1229236-86-5

Molecular Formula: C23H25ClFN7O
Molecular Weight: 469.95

Molecular Formula: C23H25ClFN7O
Molecular Weight: 469.95

Molecular Formula: C23H25ClFN7O
Molecular Weight: 469.95

Description :
LY2784544 is a potent and selective JAK2 inhibitor (IC50 = 3 nM), and exhibits less potency against JAK3 (IC50 =48 nM). LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50 = 20 and 55 nM, respectively). It reduces JAK2V617F tumor cell burden with no effect on erythroid progenitor cells.

• Molecular Weight :469.949
• Purity :> 98%

Molecular Formula :
C23H25ClFN7O
Canonical SMILES :
CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F
InChI :
InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30)
InChIKey :
SQSZANZGUXWJEA-UHFFFAOYSA-N
Appearance :
White Solid
Synonyms :
Gandotinib; LY-2784544; 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine

More details are to be found here

Description :
LY2784544 is a potent and selective JAK2 inhibitor (IC50 = 3 nM), and exhibits less potency against JAK3 (IC50 =48 nM). LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50 = 20 and 55 nM, respectively). It reduces JAK2V617F tumor cell burden with no effect on erythroid progenitor cells.

• Molecular Weight :469.949
• Purity :> 98%

Molecular Formula :
C23H25ClFN7O
Canonical SMILES :
CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F
InChI :
InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30)
InChIKey :
SQSZANZGUXWJEA-UHFFFAOYSA-N
Appearance :
White Solid
Synonyms :
Gandotinib; LY-2784544; 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine

More details are to be found here

Description :
LY2784544 is a potent and selective JAK2 inhibitor (IC50 = 3 nM), and exhibits less potency against JAK3 (IC50 =48 nM). LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50 = 20 and 55 nM, respectively). It reduces JAK2V617F tumor cell burden with no effect on erythroid progenitor cells.

• Molecular Weight :469.949
• Purity :> 98%

Molecular Formula :
C23H25ClFN7O
Canonical SMILES :
CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F
InChI :
InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30)
InChIKey :
SQSZANZGUXWJEA-UHFFFAOYSA-N
Appearance :
White Solid
Synonyms :
Gandotinib; LY-2784544; 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine

More details are to be found here