BGC > Product Search > RKI-1447 | 1342278-01-6

Molecular Formula: C16H14N4O2S
Molecular Weight: 326.38

Molecular Formula: C16H14N4O2S
Molecular Weight: 326.38

Description :
RKI-1447 is a potent Rho-associated kinase (ROCK) inhibitor with IC50 values of 14.5 and 6.2 nM for ROCK1 and ROCK2 respectively. It exhibits significant anti-invasive and antitumor activity in breast cancer. In combination with fasudil, it was shown to induce differentiation of mESCs and hESCs to endoderm via ROCK inhibition.

• Molecular Weight :326.374
• Melting Point :> 205ºC (dec.)
• Purity :> 98%

Molecular Formula :
C16H14N4O2S
Canonical SMILES :
C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3
InChI :
InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChIKey :
GDVRVPIXWXOKQO-UHFFFAOYSA-N
Appearance :
Pale Yellow Solid
Synonyms :
RKI 1447; 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea

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