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Suppliers for
Leucovorin calcium
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Properties | CAS |
1492-18-8 | Formula |
C20H21N7O7Ca | EINECS |
216-082-8 |
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4 Registered suppliers
Description : leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. - Molecular Weight :513.52
- Melting Point :240-250ēC
- Purity :> 98%
Molecular Formula : C20H21N7O7.Ca Canonical SMILES : C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.[Ca+2] InChI : InChI=1S/C20H23N7O7.Ca.H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;1H2/q;+2;/p-2/t12?,13-;;/m0../s1 InChIKey : ANIWFDFELBSPJN-RIWFDJIXSA-L Appearance : Yellow crystalline powder Storage : Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4ēC). Store protected from light and air. Synonyms : IST5-002; IST5 002; IST5002; Benzyl-AMP; N6-Benzyladenosine-5'-phosphate; Folinic acid calcium salt; Calcium Folinate
More details are to be found here
Description : leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. - Molecular Weight :513.52
- Melting Point :240-250ēC
- Purity :> 98%
Molecular Formula : C20H21N7O7.Ca Canonical SMILES : C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.[Ca+2] InChI : InChI=1S/C20H23N7O7.Ca.H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;1H2/q;+2;/p-2/t12?,13-;;/m0../s1 InChIKey : ANIWFDFELBSPJN-RIWFDJIXSA-L Appearance : Yellow crystalline powder Storage : Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4ēC). Store protected from light and air. Synonyms : IST5-002; IST5 002; IST5002; Benzyl-AMP; N6-Benzyladenosine-5'-phosphate; Folinic acid calcium salt; Calcium Folinate
More details are to be found here
Appearance:White or light yellow, amorphous or crystalline powder Content: 97.0% ~ 102.0% Use: one kind folic acid antidote, API Peculiarity:Medicine Grade Packing: 1kg/bag or 25kgs/drum Min.Order Quantity:100g Grade Standard:Medicine Grade Product Specifications: 1.PH:6.0-8.0 2.Heavy metals:NMT 0.005% 3.Water Content:NMT 17.0% 4.Calcium:7.54%~8.14% 5.Standard: USP31 Calcium folinate/leucovorin calcium/Folinic acid is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan, where it may `rescue` bone marrow and gastrointestinal mucosa cells from methotrexate. There is no apparent effect on preexisting methotrexate-induced nephrotoxicity.
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Last update 2024-04-26
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