BGC > Product Search > Birinapant | 1260251-31-7

Molecular Formula: C42H56F2N8O6
Molecular Weight: 806.9408464
HS Code: 29339900

Molecular Formula: C42H56F2N8O6
Molecular Weight: 806.9408464
HS Code: 29339900

Description :
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent.

• Molecular Weight :806.957
• Boiling Point :1090.5±65.0 °C at 760 mmHg
• Purity :> 99.50%

Molecular Formula :
C42H56F2N8O6
Canonical SMILES :
CCC(C(=O)N1CC(CC1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)CC6CC(CN6C(=O)C(CC)NC(=O)C(C)NC)O)O)NC(=O)C(C)NC
InChI :
InChI=1S/C42H56F2N8O6/c1-7-33(49-39(55)21(3)45-5)41(57)51-19-27(53)15-25(51)17-31-29-11-9-23(43)13-35(29)47-37(31)38-32(30-12-10-24(44)14-36(30)48-38)18-26-16-28(54)20-52(26)42(58)34(8-2)50-40(56)22(4)46-6/h9-14,21-22,25-28,33-34,45-48,53-54H,7-8,15-20H2,1-6H3,(H,49,55)(H,50,56)/t21-,22-,25-,26-,27-,28-,33-,34-/m0/s1
InChIKey :
PKWRMUKBEYJEIX-DXXQBUJASA-N
Solubility :
In Vitro: DMSO : 125 mg/mL(154.91 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.08 mg/mL (2.58 mM); Clear solution 2.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: 2.08 mg/mL (2.58 mM); Suspended solution; Need ultrasonic 3.Add each solvent one by one:10% DMSO > > 90%corn oil Solubility: ≥ 2.08 mg/mL (2.58 mM); Clear solution
Appearance :
white solid powder
Storage : Powder: -20°C 3 years 4°C 2 years In solvent: -80°C 6 months -20°C 1 months
Synonyms :
TL-32711; TL32711; TL 32711. Birinapant

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