BGC > Product Search > THZ1 | 1604810-83-4

Molecular Formula: C31H28ClN7O2
Molecular Weight: 566.07

Molecular Formula: C31H28ClN7O2
Molecular Weight: 566.07

Description :
THZ1 is a selective CDK7 inhibitor that preferentially diminishes transcription in cancer cells. THZ1 has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis.

• Molecular Weight :566.062
• Purity :> 98%

Molecular Formula :
C31H28ClN7O2
Canonical SMILES :
CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
InChI :
InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+
InChIKey :
OBJNFLYHUXWUPF-IZZDOVSWSA-N
Appearance :
Solid Powder
Synonyms :
HY-80013; THZ-1; HY 80013; THZ 1; HY80013; THZ1; N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide

More details are to be found here