BGC > Product Search > PA-824

Molecular Formula: C14H12F3N3O5
Molecular Weight: 359.2573896

Molecular Formula: C14H12F3N3O5
Molecular Weight: 359.2573896

Molecular Formula: C14H12F3N3O5
Molecular Weight: 359.2573896

Description :
PA-824, a bioreductive drug. PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC<1 microg/ml). PA-824 showed significant activity at 2, 10, and 50 microg/ml, similar to that of metronidazole, in a dose-dependent manner.

• Molecular Weight :359.26
• Boiling Point :462.3±55.0
• Melting Point :> 140°C
• Purity :> 98%

Molecular Formula :
C14H12F3N3O5
Canonical SMILES :
C1C(COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
InChI :
InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
InChIKey :
ZLHZLMOSPGACSZ-NSHDSACASA-N
Solubility :
<1 mg/mL
Appearance :
Solid powder
Synonyms :
PA824; PA-824; PA 824; Pretomanid.

More details are to be found here

Description :
PA-824, a bioreductive drug. PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC<1 microg/ml). PA-824 showed significant activity at 2, 10, and 50 microg/ml, similar to that of metronidazole, in a dose-dependent manner.

• Molecular Weight :359.26
• Boiling Point :462.3±55.0
• Melting Point :> 140°C
• Purity :> 98%

Molecular Formula :
C14H12F3N3O5
Canonical SMILES :
C1C(COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
InChI :
InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
InChIKey :
ZLHZLMOSPGACSZ-NSHDSACASA-N
Solubility :
<1 mg/mL
Appearance :
Solid powder
Synonyms :
PA824; PA-824; PA 824; Pretomanid.

More details are to be found here