BGC > Product Search > Necrosulfonamide | 1360614-48-7

Molecular Formula: C18H15N5O6S2
Molecular Weight: 461.4716

Molecular Formula: C18H15N5O6S2
Molecular Weight: 461.4716

Description :
Necrosulfonamide is a pharmacological inhibitor of MLKL with IC50 values of 124 nM in human HT-29, which significantly decreases BV6/DAC-induced cell death in MV4-11 cells. It prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.

• Molecular Weight :461.47
• Purity :≥98% by HPLC

Molecular Formula :
C18H15N5O6S2
Canonical SMILES :
COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]
InChI :
InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+
InChIKey :
FNPPHVLYVGMZMZ-XBXARRHUSA-N
Solubility :
DMSO to 20 mM
Appearance :
Yellow solid
Storage : Store in a cool and dry place (or refer to the Certificate of Analysis).
Synonyms :
(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

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