BGC > Product Search > Hydroxyfasudil hydrochloride | 155558-32-0

Molecular Formula: C14H18ClN3O3S
Molecular Weight: 343.82902
Hazard Symbols: Xn
WGKGermany: 3

Description :
Hydroxyfasudil Hydrochloride, an active metabolite of Fasudil, preferentially inhibits Rho-kinase and plays a central role in the pathogenesis of coronary artery spasm. It is reported to inhibit neutrophil migration and exhibit potent vasodilatory effects in vivo.

• Molecular Weight :343.826
• Melting Point :> 250ºC (dec.)
• Purity :> 98%

Molecular Formula :
C14H18ClN3O3S
Canonical SMILES :
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
InChI :
InChI=1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
InChIKey :
XWWFOUVDVJGNNG-UHFFFAOYSA-N
Appearance :
White to Off-white Solid
Synonyms :
HA 1100 hydrochloride; HA1100 hydrochloride; HA-1100 hydrochloride; 5-(1,4-diazepan-1-ylsulfonyl)-2~{H}-isoquinolin-1-one hydrochloride; 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride

More details are to be found here

Description :
Hydroxyfasudil Hydrochloride, an active metabolite of Fasudil, preferentially inhibits Rho-kinase and plays a central role in the pathogenesis of coronary artery spasm. It is reported to inhibit neutrophil migration and exhibit potent vasodilatory effects in vivo.

• Molecular Weight :343.826
• Melting Point :> 250ºC (dec.)
• Purity :> 98%

Molecular Formula :
C14H18ClN3O3S
Canonical SMILES :
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
InChI :
InChI=1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
InChIKey :
XWWFOUVDVJGNNG-UHFFFAOYSA-N
Appearance :
White to Off-white Solid
Synonyms :
HA 1100 hydrochloride; HA1100 hydrochloride; HA-1100 hydrochloride; 5-(1,4-diazepan-1-ylsulfonyl)-2~{H}-isoquinolin-1-one hydrochloride; 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride

More details are to be found here

Description :
Hydroxyfasudil Hydrochloride, an active metabolite of Fasudil, preferentially inhibits Rho-kinase and plays a central role in the pathogenesis of coronary artery spasm. It is reported to inhibit neutrophil migration and exhibit potent vasodilatory effects in vivo.

• Molecular Weight :343.826
• Melting Point :> 250ºC (dec.)
• Purity :> 98%

Molecular Formula :
C14H18ClN3O3S
Canonical SMILES :
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
InChI :
InChI=1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
InChIKey :
XWWFOUVDVJGNNG-UHFFFAOYSA-N
Appearance :
White to Off-white Solid
Synonyms :
HA 1100 hydrochloride; HA1100 hydrochloride; HA-1100 hydrochloride; 5-(1,4-diazepan-1-ylsulfonyl)-2~{H}-isoquinolin-1-one hydrochloride; 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride

More details are to be found here