Suppliers for CAS
1037624-75-1
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Properties | CAS |
1037624-75-1 | Formula |
C30H34N8 |
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7 Registered suppliers
Amadis Chemical Company Limited
P.R.China
More details are to be found here
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C30H34N8 Molecular Weight: 506.64456
Aea.ltd
P.R.China
Molecular Formula: C30H34N8 Molecular Weight: 506.64456
Molecular Formula: C30H34N8 Molecular Weight: 506.64456
Finetech Industry Limited
P.R.China
More details are to be found here
BOC Sciences
USA
Description : Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, > 80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metastatic tumors. - Molecular Weight :506.658
Molecular Formula : C30H34N8 Canonical SMILES : C1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76 InChI : InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1 InChIKey : KXMZDGSRSGHMMK-VWLOTQADSA-N Synonyms : BGB324; BGB-324; BGB 324; R 428; R-428; R428; 1-(6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine
More details are to be found here
Ambeed, Inc.
USA
Purity : 98% Smile code : NC1=NC(NC2=CC=C3C(CC[C@@H](N4CCCC4)CC3)=C2)=NN1C5=NN=C6C(CCCC7=CC=CC=C76)=C5 MDL Number : MFCD21608463 MolFormula : C30H34N8 MolWeight : 506.6446 Available in stock : 1.705
More details are to be found here
BLD Pharmatech Ltd
P.R.China
Smile code: NC1=NC(NC2=CC=C3C(CC[C@@H](N4CCCC4)CC3)=C2)=NN1C5=NN=C6C(CCCC7=CC=CC=C76)=C5 MDL Number: MFCD21608463 Purity : 98% Available in stock: 11.501 g
More details are to be found here
Detailed information on the suppliers of
R428
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