BGC > Product Search > Avagacestat | 1146699-66-2

Molecular Formula: C20H17ClF4N4O4S
Molecular Weight: 520.8849928

Molecular Formula: C20H17ClF4N4O4S
Molecular Weight: 520.8849928

Molecular Formula: C20H17ClF4N4O4S
Molecular Weight: 520.8849928

Description :
BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM).

• Molecular Weight :520.89
• Boiling Point :652.258 °C at 760 mmHg
• Purity :> 98%

Molecular Formula :
C20H17ClF4N4O4S
Canonical SMILES :
C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl
InChI :
InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1
InChIKey :
XEAOPVUAMONVLA-QGZVFWFLSA-N
Solubility :
Soluble to 100 mg/mL in DMSO, to 7.5 mg/mL in Ethanol.
Appearance :
Solid Powder
Application :
Gamma Secretase Inhibitors and Modulators
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -34℃ for long term (months to years).
Synonyms :
Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide

More details are to be found here

Description :
BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM).

• Molecular Weight :520.89
• Boiling Point :652.258 °C at 760 mmHg
• Purity :> 98%

Molecular Formula :
C20H17ClF4N4O4S
Canonical SMILES :
C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl
InChI :
InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1
InChIKey :
XEAOPVUAMONVLA-QGZVFWFLSA-N
Solubility :
Soluble to 100 mg/mL in DMSO, to 7.5 mg/mL in Ethanol.
Appearance :
Solid Powder
Application :
Gamma Secretase Inhibitors and Modulators
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -34℃ for long term (months to years).
Synonyms :
Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide

More details are to be found here