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Suppliers for
Dolutegravir
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Properties | CAS |
1051375-16-6 | Formula |
C20H19F2N3O5 |
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14 Registered suppliers
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Description : Dolutegravir is a two-metal-binding HIV-1 integrase inhibitor with IC50 of 2.7 nM, with modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. It blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). - Molecular Weight :419.38
- Boiling Point :669.0±55.0 °C at 760 mmHg
- Purity :≥98%
Molecular Formula : C20H19F2N3O5 Canonical SMILES : CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O InChI : InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1 InChIKey : RHWKPHLQXYSBKR-BMIGLBTASA-N Solubility : In Vitro: DMSO : 10 mg/mL(23.84 mM;Need ultrasonic and warming) In Vivo: 1.Add each solvent one by one:5% DMSO > > 95% (20%SBE-β-CDin saline) Solubility: ≥ 2.62 mg/mL (6.25 mM); Clear solution 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution 4.Add each solvent one by one:10% DMSO > > 90%corn oil Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution Appearance : White to off-white (Solid) Storage : Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month Synonyms : GSK-1349572; GSK 1349572; GSK1349572; Tivicay
More details are to be found here
Description : Dolutegravir is a two-metal-binding HIV-1 integrase inhibitor with IC50 of 2.7 nM, with modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. It blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). - Molecular Weight :419.38
- Boiling Point :669.0±55.0 °C at 760 mmHg
- Purity :≥98%
Molecular Formula : C20H19F2N3O5 Canonical SMILES : CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O InChI : InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1 InChIKey : RHWKPHLQXYSBKR-BMIGLBTASA-N Solubility : In Vitro: DMSO : 10 mg/mL(23.84 mM;Need ultrasonic and warming) In Vivo: 1.Add each solvent one by one:5% DMSO > > 95% (20%SBE-β-CDin saline) Solubility: ≥ 2.62 mg/mL (6.25 mM); Clear solution 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution 4.Add each solvent one by one:10% DMSO > > 90%corn oil Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution Appearance : White to off-white (Solid) Storage : Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month Synonyms : GSK-1349572; GSK 1349572; GSK1349572; Tivicay
More details are to be found here
Description : Dolutegravir is a two-metal-binding HIV-1 integrase inhibitor with IC50 of 2.7 nM, with modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. It blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). - Molecular Weight :419.38
- Boiling Point :669.0±55.0 °C at 760 mmHg
- Purity :≥98%
Molecular Formula : C20H19F2N3O5 Canonical SMILES : CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O InChI : InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1 InChIKey : RHWKPHLQXYSBKR-BMIGLBTASA-N Solubility : In Vitro: DMSO : 10 mg/mL(23.84 mM;Need ultrasonic and warming) In Vivo: 1.Add each solvent one by one:5% DMSO > > 95% (20%SBE-β-CDin saline) Solubility: ≥ 2.62 mg/mL (6.25 mM); Clear solution 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution 4.Add each solvent one by one:10% DMSO > > 90%corn oil Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution Appearance : White to off-white (Solid) Storage : Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month Synonyms : GSK-1349572; GSK 1349572; GSK1349572; Tivicay
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Properties:
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Last update 2024-04-26
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