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Suppliers for
Chrysophanol
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Properties | CAS |
481-74-3 | Formula |
C15H10O4 | EINECS |
207-572-2 |
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9 Registered suppliers
Appearance | Orange Powder
| Odor &Taste | Characteristic
| Specification | 98%
| Active Ingredient | Chrysophanol / Chrysophanic Acid
| Sieve Analysis | NLT 100% pass 80 mesh
| Loss on Drying | ≤ 4.0%
| Ash content | ≤ 2.0%
| Ethanol | <=5000ppm
| Total Heavy Metals | ≤ 20ppm
| Total Plate Count | ≤ 1000cfu/g
| Total Yeast & Mold | ≤ 100cfu/g |
Description : Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 µm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material. - Molecular Weight :254.24
- Boiling Point :Sublimes
- Melting Point :194-197 ℃
- Purity :≥ 98 %
Molecular Formula : C15H10O4 Canonical SMILES : CC1=CC(=C2C(=C1)C(=O)C3=C(C2=O)C(=CC=C3)O)O InChI : InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3 InChIKey : LQGUBLBATBMXHT-UHFFFAOYSA-N Solubility : less than 1 mg/mL at 64 °F Appearance : Orange solid Application : anti-inflammatory Synonyms : 1,8-dihydroxy-3-methylanthracene-9,10-dione
More details are to be found here
Purity : 98% Smile code : O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O MDL Number : MFCD00001208 MolFormula : C15H10O4 MolWeight : 254.2375 Available in stock : 13.097
More details are to be found here
Purity : 98% Smile code : O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O MDL Number : MFCD00001208 MolFormula : C15H10O4 MolWeight : 254.2375 Available in stock : 13.097
More details are to be found here
Purity : 98% Smile code : O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O MDL Number : MFCD00001208 MolFormula : C15H10O4 MolWeight : 254.2375 Available in stock : 13.097
More details are to be found here
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Properties:
... more properties and specification on Chrysophanol
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Last update 2024-04-29
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