BGC > Product Search > Batefenterol | 743461-65-6

Molecular Formula: C40H42ClN5O7
Molecular Weight: 740.24378

Molecular Formula: C40H42ClN5O7
Molecular Weight: 740.24378

Description :
Batefenterol is a Beta 2 adrenergic receptor agonist and also a Muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). Batefenterol is a hβ2-adrenoceptor agonist with EC50 value of 0.29 nM for stimulation of cAMP levels. This is 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors. In Jul 2016, GlaxoSmithKline completed a phase II trial for Chronic obstructive pulmonary disease in USA, Germany and South Africa.

• Molecular Weight :740.25
• Purity :98%

Molecular Formula :
C40H42ClN5O7
Canonical SMILES :
COc1cc(c(cc1CNC[C@@H](c2ccc(c3c2ccc(=O)[nH]3)O)O)Cl)NC(=O)CCN4CCC(CC4)OC(=O)Nc5ccccc5c6ccccc6
InChI :
1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30(29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(16-19-46)53-40(51)44-32-10-6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H,15-20,23-24H2,1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1
InChIKey :
URWYQGVSPQJGGB-DHUJRADRSA-N
Solubility :
Soluble in DMSO
Appearance :
Powder
Application :
Chronic obstructive pulmonary disease
Storage : -20℃ Freezer
Synonyms :
GSK-961081; TD-5959; GSK 961081; TD 5959; GSK961081; TD5959; (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

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