Suppliers for CAS
1034616-18-6
|
Properties | CAS |
1034616-18-6 | Formula |
C24H27F3N8O3 |
|
4 Registered suppliers
Amadis Chemical Company Limited
P.R.China
More details are to be found here
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C24H27F3N8O3 Molecular Weight: 532.5181896
Aea.ltd
P.R.China
Molecular Formula: C24H27F3N8O3 Molecular Weight: 532.5181896
BOC Sciences
USA
Description : NMS1286937, also know as NMS-P937, is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis. - Molecular Weight :532.53
- Purity :> 98%
Molecular Formula : C24H27F3N8O3 Canonical SMILES : CN1CCN(CC1)C2=CC(=C(C=C2)OC(F)(F)F)NC3=NC=C4CCC5=C(C4=N3)N(N=C5C(=O)N)CCO InChI : InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31) InChIKey : QHLVBNKYJGBCQJ-UHFFFAOYSA-N Appearance : Solid powder Application : Protein Kinase Inhibitors Synonyms : PCM-075; PCM 075; PCM075; NMS1286937; NMS 1286937; NMS-1286937; NMS-P937; NMS-P-937; NMS-P 937; Onvansertib
More details are to be found here
|