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Suppliers for
NLG919
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Properties | CAS |
1402836-58-1 |
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3 Registered suppliers
Molecular Formula: C18H22N2O Molecular Weight: 282.39
Molecular Formula: C18H22N2O Molecular Weight: 282.39
Description : NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). - Molecular Weight :282.38
- Melting Point :143 - 146°C
- Purity :> 98%
Molecular Formula : C18H22N2O Canonical SMILES : C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O InChI : 1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2 InChIKey : YTRRAUACYORZLX-UHFFFAOYSA-N Solubility : DMSO 15 mg/mL heating; Water < 1 mg/ml Appearance : White solid Storage : Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Synonyms : GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078.
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NLG919
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Last update 2024-04-30
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