BGC > Product Search > (-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one | 675576-98-4

Molecular Formula: C30H30Cl2N4O4
Molecular Weight: 581.497
Hazard Symbols: Xn
WGKGermany: 3

Molecular Formula: C30H30Cl2N4O4
Molecular Weight: 581.497
Hazard Symbols: Xn
WGKGermany: 3

Description :
Nutlin-3a is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin-3a activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein.

• Molecular Weight :581.5
• Purity :> 98%

Molecular Formula :
C30H30Cl2N4O4
Canonical SMILES :
CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
InChI :
InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
InChIKey :
BDUHCSBCVGXTJM-WUFINQPMSA-N
Solubility :
Soluble in DMSO (5 mg/mL)
Appearance :
white solid powder
Synonyms :
rebemadlin; (-)-Nutlin-3; Nutlin-3a chiral

More details are to be found here

Formula:
C30H30Cl2N4O4
Mol Weight:
581,49g/mol
Synonym:
(-)-Nutlin-3, 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one,4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1 -methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2

More details are to be found here