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Suppliers for
MMAE
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Properties | CAS |
474645-27-7 | Formula |
C39H67N5O7 |
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2 Registered suppliers
Description : Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. - Molecular Weight :717.98
- Boiling Point :873.5±65.0 °C at 760 mmHg
- Melting Point :> 90°C (dec.)
- Purity :≥98.0% by HPLC
Molecular Formula : C39H67N5O7 Canonical SMILES : CC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC InChI : InChI=1S/C39H67N5O7/c1-13-25(6)34(43(10)39(49)33(24(4)5)42-38(48)32(40-9)23(2)3)30(50-11)22-31(45)44-21-17-20-29(44)36(51-12)26(7)37(47)41-27(8)35(46)28-18-15-14-16-19-28/h14-16,18-19,23-27,29-30,32-36,40,46H,13,17,20-22H2,1-12H3,(H,41,47)(H,42,48)/t25-,26+,27+,29-,30+,32-,33-,34-,35+,36+/m0/s1 InChIKey : DASWEROEPLKSEI-UIJRFTGLSA-N Solubility : Soluble in DMSO (Slightly), Methanol (Slightly, Sonicated); Insoluble in Water Appearance : White to Off-white Solid Application : ADCs Cytotoxin Storage : Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) Synonyms : MMAE; Vedotin; Monomethyl auristatin E; Monomethylauristatin E; N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
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MMAE
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Properties:
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Last update 2024-05-30
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