BGC > Buscar Producto > Jak3 inhibitor i | 202475-60-3

Molecular Formula: C16H15N3O3
Molecular Weight: 297.31
Hazard Symbols: Xi
WGKGermany: 3

Description:
A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.

• Molecular Weight:297.31
• Purity:>98%

Molecular Formula:
C16H15N3O3
Canonical SMILES:
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC
InChI:
InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
InChIKey:
HOZUXBLMYUPGPZ-UHFFFAOYSA-N
Synonyms:
WHI-P131, WHI P-131, WHI P131, Janex 1